Joint damage and QoL for PwH

Joint damage and QoL for PwH

Joint damage can have a profound effect on patients’ quality of life1,2

Joint bleeds have been reported to account for up to 90% of serious bleeding events in patients3

Over time, complications from recurrent haemarthrosis can result in severe arthropathy, leading to chronic pain, disability and impairment of health-related quality of life1,4


Life-long joint arthropathy and pain should not be the accepted norm of a haemophilia diagnosis. Isn’t it time to give your patients a fresh perspective on life?

PwH, people with haemophilia; Qol, quality of life; rFVIII, recombinant Factor VIII.


1. Knobe K, Berntorp E. Haemophilia and joint disease: pathophysiology, evaluation, and management. J Comorb. 2011 Dec;1:51–9.

2. Wyseure T, Mosnier LO, von Drygalski A. Advances and Challenges in Hemophilic Arthropathy. Semin Hematol. 2016 Jan;53(1):10–9.

3. Valentino LA. Blood-induced joint disease: the pathophysiology of hemophilic arthropathy. J Thromb Haemost. 2010 Sep;8(9):1895-902.

4. Oldenburg J, Kulkarni R, Srivastava A, Mahlangu JN, Blanchette VS, Tsao E. Improved joint health in subjects with severe haemophilia A treated prophylactically with recombinant factor VIII Fc fusion protein. Haemophilia. 2018 Jan;24(1):77–84.