Every bleed has an impact

Every bleed has an impact

Joint bleeds can cause a progressive deterioration in joint health1
  • The onset of joint arthropathy largely depends on the number of joint bleeds per year, although some patients are more susceptible to bleeds than others1
Just one joint bleed can cause permanent damage and trigger a lasting deterioration in joint health2,3
  • Joint bleeding is believed to trigger a synovial over-reaction which may progress even without further bleeds2
  • Inflammation appears to be pivotal in the pathogenic cascade of haemophilic arthropathy2

Personalised prophylaxis from early on can prevent joint bleeds, offer sustained joint protection throughout life and thus improve the quality of life of people with haemophilia1,4


  1. Oldenburg J. Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens. Blood. 2015 Mar 26;125(13)2038–44.

  2. Melchiorre D, Manetti M, Matucci-Cerinic M. Pathophysiology of Hemophilic Arthropathy. J Clin Med. 2017 Jul;6(7):63.

  3. Gringeri A, Ewenstein B, Reininger A. The burden of bleeding in haemophilia: is one bleed too many? Haemophilia 2014 Jul;20(4)459–63.

  4. Oldenburg J, et al. EAHAD 2019 Poster P158.